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A sample of 384 teenagers was obtained based on the prevalence of smoking among teenagers

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Goodrick-Clarke 2002, pp

Cigarette smoke contains a large number of toxic substances, including a large number of oxygen metabolite-derived or reactive oxygen species (ROS), which can directly disrupt this physical barrier, resulting in increased permeability of respiratory epithelial cells and hindering clearance of mucus cilia [28]

"We have very low rates of smoking that are going lower, and we don't need to experiment with something like e-cigarettes at the moment," Professor Matthew Peters, Head of Respiratory Medicine at Concord Hospital in Sydney, told The Health Report